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Mutation in codon 200 of scrapie amyloid protein gene in two clusters of Creutzfeldt-Jakob disease in Slovakia

✍ Scribed by Goldfarb, LevG.; Mitrová, Eva; Brown, Paul; Hock Toh, Ban; Carleton Gajdusek, D.


Book ID
122560447
Publisher
The Lancet
Year
1990
Tongue
English
Weight
489 KB
Volume
336
Category
Article
ISSN
0140-6736

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Creutzfeldt-Jakob disease (CJD) belongs to a group of chronic, progressive, neurodegenerative disorders that may be hereditary, infectious, or sporadic. Hereditary CJDs are associated with mutations in the PRNP gene on chromosome 20p12-pter. We report a family in which four patients developed classi