Mutation effects on structural stability of polyglutamine peptides by molecular dynamics simulation
β Scribed by Miki Nakano; Hirofumi Watanabe; E.B. Starikov; Stuart M. Rothstein; Shigenori Tanaka
- Book ID
- 107661833
- Publisher
- International Association of Scientists in the Interdisciplinary Areas
- Year
- 2009
- Tongue
- English
- Weight
- 543 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1913-2751
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π SIMILAR VOLUMES
The effects of alcohols on local protein structure have been simulated using computational approaches and model peptides. Molecular simulations were carried out on a 7-residue peptide created in both an extended conformation and an β£-helix to explore alcohol-induced changes in peptide structure. It
## Abstract The nanoscale peptide YSGVCHTDLHAWHGDWPLPVK exhibits molecular chaperone activity and prevents protein aggregation under chemical and/or thermal stress. Here, His mutations of this peptide and their impact on chaperone activity were evaluated using theoretical techniques. Molecular dyna
data regarding the behavior of peptides at the waterαmembrane interface. An analysis of the conformational dynamics of the signal sequence peptide at the interface was performed over the course of a few nanoseconds.