Mutation and DNA modification in Salmonella exposed to N-nitrosodimethylamine under UVA- and sunlight-irradiation

Induced mutations in M13mp2 phage DNA ex

Induced mutations in M13mp2 phage DNA exposed to N-nitrosopyrrolidine with UVA irradiation

✍ Sakae Arimoto-Kobayashi; Naomi Inada; Nobuko Anma; Hiromi Shimada; Hikoya Hayats 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 111 KB

It is known that N-nitrosopyrrolidine (NPYR), a carcinogen in rodents, is metabolically activated by microsomal cytochrome P450 to form an ␣-hydroxylated derivative, which induces mutations. The mutations have been demonstrated by use of Salmonella typhimurium and Escherichia coli. We discovered dir