## Communicated by David Ginsburg Bruton's tyrosine kinase (Btk) has been identified as the protein responsible for the primary immunodeficiency X-linked agammaglobulinemia (XLA) and has been described as a new member of Srcrelated cytoplasmic protein tyrosine kinases. We have recently characteriz
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Mutation analysis of the gene encoding Bruton's tyrosine kinase in a family with a sporadic case of X-linked agammaglobulinemia reveals three female carriers
โ Scribed by Hagemann, Tracy L. ;Assa'ad, Amal H. ;Kwan, Sau-Ping
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 586 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0148-7299
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X-linked agammaglobulinemia (XLA) is an inherited immunodeficiency disease with a block in differentiation from pre-B to B cells resulting in a selective defect in the humoral immune response. Affected males have very low concentrations of serum immunoglobulins leading predominantly to recurrent bac