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Mutation analysis of the DNA-damage checkpoint gene CHK2 in myelodysplastic syndromes and acute myeloid leukemias

โœ Scribed by Wolf-K. Hofmann; Carl W. Miller; Kunihiro Tsukasaki; Sigal Tavor; Takayuki Ikezoe; Dieter Hoelzer; Seisho Takeuchi; H.Phillip Koeffler


Book ID
114118948
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
132 KB
Volume
25
Category
Article
ISSN
0145-2126

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The primary pathology in many cases of myelodysplasia (MDS) and acute myeloid leukemia (AML) remains unknown. In some cases, two or more affected members have been identified in the same family. To date, mutations in two genes have been directly implicated: the hematopoietic transcription factors RU