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Mutation analysis of five candidate genes in familial breast cancer

โœ Scribed by Anna Marsh; Sue Healey; Aaron Lewis; Amanda B. Spurdle; Mary Anne Kedda; Kum Kum Khanna; kConFab; Graham J. Mann; Gulietta M. Pupo; Sunil R. Lakhani; Georgia Chenevix-Trench


Publisher
Springer US
Year
2006
Tongue
English
Weight
187 KB
Volume
105
Category
Article
ISSN
0167-6806

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Family history is a well-recognized risk factor for the development of breast cancer. The isolation of BRCA1 and BRCA2 genes, the two major predisposing genes in familial and to early onset breast and ovarian cancer, has resulted to the identification of a large number of families with mutations in