Mutation analysis and hfe sequencing of two families with iron overload
β Scribed by D. Barisani; D. Conte; E. Ginelli; M. Cocciolo; B. Fornarini; R. Meneveri
- Book ID
- 118564539
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 140 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0168-8278
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π SIMILAR VOLUMES
Mild to moderate hepatic iron overload is frequent in patients with chronic viral hepatitis (CH). We evaluated the role of hemochromatosis (HFE) gene mutations and other acquired factors in the development of iron overload in these patients. We studied 110 patients with chronic B or C viral hepatiti
Hereditary hemochromatosis is a common-recessive-autosomal disease characterized by progressive iron overload, and its prevalence correlates with c.845G>A (p. C282Y) mutation of the HFE gene. Two other variants c.187C>G and c.193A>T are associated with a mild iron overload phenotype. The correlation