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Mutation Analyses of 268 Candidate Genes in Human Tumor Cell Lines

✍ Scribed by David H.-F. Teng; Yuan Chen; Lubing Lian; Phoung C. Ha; Sean V. Tavtigian; Alexander K.C. Wong

Book ID
115615453
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
116 KB
Volume
74
Category
Article
ISSN
0888-7543

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Loss of heterozygosity (LOH) on chromosome 10 is the most common genetic changes in glioblastomas of World Health Organization (WHO) Grade IV. [1][2][3][4][5][6][7] In most cases, the allelic losses involve loci along the entire chromosome, a finding in line with monosomy 10. LOH on chromosome 10 ma