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Mutated tau binds less avidly to microtubules than wildtype tau in living cells

โœ Scribed by E. Ewa Nagiec; Kathleen E. Sampson; Irene Abraham


Book ID
101338248
Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
314 KB
Volume
63
Category
Article
ISSN
0360-4012

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Missense and splicing point mutations have been found in the tau gene in families with frontotemporal dementia with parkinsonism linked to chromosome 17 . Of these mutations, we examined four exonic missense point mutations (G272V, P301L, V337M and R406W) in 3-repeat or 4-repeat tau isoform on the t