Mutated APC and Asef are involved in the migration of colorectal tumour cells
β Scribed by Kawasaki, Yoshihiro; Sato, Rina; Akiyama, Tetsu
- Book ID
- 109912651
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 447 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1465-7392
- DOI
- 10.1038/ncb937
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The roles of the intrinsic mutation rate and genomic instability in tumorigenesis are currently controversial. In most colorectal tumours, it is generally supposed that the first mutations occur at the adenomatous polyposis coli (APC) locus; APC mutations are thought to provide cells with a selectiv
Colorectal adenomas are macroscopically visible morphological changes of the mucosa that can develop focal carcinoma in the absence of surgical intervention. The successive molecular changes proposed to occur at different stages in the adenomacarcinoma sequence were primarily based on DNA studies of