𝔖 Bobbio Scriptorium
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Mutants of Aspergillus nidulans with increased resistance to the alkylating agent, N-methyl-N′-nitro-N-nitrosoguanidine

✍ Scribed by P. Hooley; S.G. Shawcross; P. Strike


Book ID
116108242
Publisher
Elsevier Science
Year
1988
Weight
598 KB
Volume
193
Category
Article
ISSN
0167-8817

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## Abstract We examined the action of __N__‐methyl‐__N′__‐nitro‐__N__‐nitrosoguanidine (MNNG) on HeLa cells and compared it with that of cisplatin (CP). MNNG directly killed a substantial number of cells within 1 hour and resulted in strong DNA‐damage as evidenced by Comet measurements. Despite app