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Mutant presenilin 2 increased oxidative stress and p53 expression in neuronal cells

✍ Scribed by Hong Nga Nguyen; Moon Soon Lee; Dae Youn Hwang; Young Kyu Kim; Do Young Yoon; Jae Woong Lee; Yeo Pyo Yun; Myung Koo Lee; Ki Wan Oh; Jin Tae Hong

Book ID
116294711
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
783 KB
Volume
357
Category
Article
ISSN
0006-291X

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## Abstract Oxidative stress is associated with β‐amyloid peptide (AΞ²) accumulation in the brains of Alzheimer's disease patients. AΞ² is generated upon the sequential proteolytic cleavage of transmembrane amyloid precursor protein (APP) by two membrane‐bound proteases, β‐secretase (BACE1) and the Ξ³