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Mutant presenilin 2 causes abnormality in the brain lipid profile in the development of Alzheimer’s disease

✍ Scribed by Hong Nga Nguyen; Dong Ju Son; Jae Woong Lee; Dae Youn Hwang; Young Kyu Kim; Jeong Sik Cho; Ung Soo Lee; Hwan Soo Yoo; Dong Cheul Moon; Ki Wan Oh; Jin Tae Hong

Book ID
105671622
Publisher
Springer
Year
2006
Tongue
English
Weight
809 KB
Volume
29
Category
Article
ISSN
0253-6269

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## Abstract Accumulating evidence has indicated that gain‐of‐function in β‐amyloid production may be not the necessary mechanism for mutant presenilin‐1 (PS1) or PS2 to cause familial Alzheimer's disease (AD). In the present article, we show that conditional knockout of PS1 from the adult stage in