Mutant molecular motors disrupt neural circuits inDrosophila
✍ Scribed by Reddy, S. ;Jin, P. ;Trimarchi, J. ;Caruccio, P. ;Phillis, R. ;Murphey, R. K.
- Book ID
- 101258314
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 470 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0022-3034
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✦ Synopsis
A dominant negative mutation, but this resistance reflex was nearly absent in mutant Glued 1 , that codes for a component of the dynactin animals. We used the P[Gal4] insertion strains to tarcomplex, disrupted the axonal anatomy of leg sensory get expression of tetanus toxin light chain to these neurons in Drosophila. To examine neuron structure sensory neurons in wild-type animals and showed that in mutant animals, a P[Gal4] enhancer trap targeted this blocked the resistance reflex and produced a pheexpression of lacZ to the sensory neurons and thereby nocopy of the Glued result. We conclude that disruplabeled neurons in the femoral chordotonal organ and tion of the dynein-dynactin complex disrupts sensory their axons within the central nervous system. When axon path finding during metamorphosis, and this in these sensory axons were examined in the Glued 1 muturn disrupts synaptic connectivity. ᭧ 1997 John tant specimens, they were observed to arborize abnor-