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Mutant GTP cyclohydrolase I mRNA levels contribute to dopa-responsive dystonia onset

โœ Scribed by Makito Hirano; Yoshiko Tamaru; Hidefumi Ito; Sadayuki Matsumoto; Terukuni Imai; Dr Satoshi Ueno


Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
317 KB
Volume
40
Category
Article
ISSN
0364-5134

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Dopa-responsive dystonia and early-onset
โœ Lena Elisabeth Hjermind; Lis Gitte Johannsen; Nenad Blau; Ron Allan Wevers; Chri ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 94 KB

We describe a patient with a combination of dystonic and parkinsonian signs. Paraclinical studies revealed a mutation in the GTP cyclohydrolase I gene (GCH1) and a decrease in [ 123 I]-N--fluoropropyl-2โค-carbomethoxy-3โค-(4iodophenyl) nortropane ( 123 I-FP-CIT) binding ratios indicative of Parkinson'