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Mutant epidermal growth factor receptor displays increased signaling through the phosphatidylinositol-3 kinase/AKT pathway and promotes radioresistance in cells of astrocytic origin

✍ Scribed by Li, Bin; Yuan, Min; Kim, In-Ah; Chang, Chi-Ming; Bernhard, Eric J; Shu, Hui-Kuo G


Book ID
110068676
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
288 KB
Volume
23
Category
Article
ISSN
0950-9232

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Inhibition of phosphatidylinositol 3-kin
✍ Manuela Klingler-Hoffmann; Patricia Bukczynska; Tony Tiganis πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 French βš– 599 KB

## Abstract In __de novo__ glioblastoma multiforme, loss of the tumour suppressor protein PTEN can coincide with the expression of a naturally occurring mutant epidermal growth factor receptor known as Ξ”EGFR. Ξ”EGFR signals constitutively via the phosphatidylinositol 3‐kinase (PI3K)/protein kinase A