Inhibition of phosphatidylinositol 3-kin
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Manuela Klingler-Hoffmann; Patricia Bukczynska; Tony Tiganis
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Article
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2003
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John Wiley and Sons
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French
β 599 KB
## Abstract In __de novo__ glioblastoma multiforme, loss of the tumour suppressor protein PTEN can coincide with the expression of a naturally occurring mutant epidermal growth factor receptor known as ΞEGFR. ΞEGFR signals constitutively via the phosphatidylinositol 3βkinase (PI3K)/protein kinase A