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Mutagens in rat urine after dermal application of 1,3-diaminobenzene

✍ Scribed by Steen Clemmensen; Henrik Rye Lam


Book ID
119092643
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
451 KB
Volume
138
Category
Article
ISSN
0165-1218

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3-hydroxy-benzo(a)pyrene (3-OH-B(a)P) and mutagenic activity in rat urine were determined after the oral administration of benzo(a)pyrene given in three repeated doses of 10, 20 and 50 pmol kg-'. The procedure for the determination of 3-OH-B(a)P consisted of enzymic hydrolysis, separation and HPLC-a