✦ LIBER ✦

Mutagenicity studies with praziquantel, a new anthelmintic drug: Tissue-, host-, and urine-mediated mutagenicity assays

✍ Scribed by J. Obermeier; H. Frohberg

Book ID: 104708661
Publisher: Springer-Verlag
Year: 1977
Tongue: English
Weight: 681 KB
Volume: 38
Category: Article
ISSN: 0340-5761
DOI: 10.1007/bf00293649

No coin nor oath required. For personal study only.

✦ Synopsis

Praziquantel, a new anthelmintic drug with activity against all species of schistosomes pathogenic to man, and against a wide range of Cestodes, was tested for mutagenic potential. For the detection of both base substitutions and frameshift mutations, Salmonella typhimurium TA 100 and TA 98 were used as tester strains. Using the plate assay with and without added S-9, host-mediated assay and urine-mediated assay without and after incubation with beta-glucuronidase/arylsulfatase, no mutagenic activity could be detected.

📜 SIMILAR VOLUMES

Mutagenicity studies with Praziquantel,

Mutagenicity studies with Praziquantel, a new anthelmintic drug, in mammalian systems

✍ L. Machemer; D. Lorke 📂 Article 📅 1978 🏛 Springer-Verlag 🌐 English ⚖ 650 KB

Praziquantel, a new anthelmintic drug with antischistosomal and anticestodal properties, was tested in comparison with a placebo control and a 'positive control' with cyclophosphamide in mammalian test systems in vivo for potential mutagenic effects. The test systems used and the tested doses of Pra