Mutagenicity of some benzidine congeners and theirN-acetylated andN,N′-diacetylated derivatives in different strains ofSalmonella typhimurium
✍ Scribed by Reid, Thomas M. ;Wang, Ching Y. ;King, Charles M. ;Morton, Kenneth C.
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1984
- Weight
- 381 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0192-2521
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✦ Synopsis
The Ames Salmonella/microsome test was used to compare the mutagenic response of Salmonella typhimurium TA100, TA98, TA1538, and TA1535 to 12 benzidine derivatives, ie, benzidine, 3,3'-dimethoxybenzidine, 3,3'-dimethylbenzidine, 3,3'-dichlorobenzidine, and the corresponding N-and N , N'-diacetylated derivatives. With a few exceptions, the mutagenic response to this series of compounds varied in the order TA98 > TA1538 > TA100 > TA1535 = 0, and the N-monoacetylated derivatives were more mutagenic than either the parent diarnines or the N,N'-diacetyl derivatives. The relative rnutagenicities of the parent amines for TA98 were 3,3'-dichlorobenzidine > > 3,3'-dirnethoxybenzidine > benzidine > 3,3'-dimethylbenzidine.