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Mutagenicity of p-aminophenol in E. coli WP2uvrA/pKM101 and its relevance to oxidative DNA damage

✍ Scribed by Rie Yoshida; Shinji Oikawa; Yasutaka Ogawa; Yuichi Miyakoshi; Motoi Ooida; Kazunari Asanuma; Hidesuke Shimizu


Book ID
117767620
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
555 KB
Volume
415
Category
Article
ISSN
1383-5718

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Accelerated repair and reduced mutagenic
✍ Monica Ropolo; Alessandro Geroldi; Paolo Degan; Virginia Andreotti; Simona Zupo; πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 French βš– 703 KB

## Abstract Repair of some oxidized purines such as 8‐oxo‐7,8‐dihydroguanine (8‐oxoG) is inefficient in human cells in comparison to repair of other major endogenous lesions (__e.g.__ uracil, abasic sites or oxidized pyrimidines). This is due to the poor catalytic properties of hOGG1, the major DNA