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Mutagenicity of N-nitrosomorpholine biosynthesized from morpholine in the presence of nitrate and its inhibition by ascorbic acid

✍ Scribed by Pérez, A. ;Fernández, S. I. ;Garcia-Roché, M. O. ;De Las Cagigas, A. ;Castillo, A. ;Fonseca, G. ;Herrera, M.

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 193 KB
Volume: 34
Category: Article
ISSN: 0027-769X
DOI: 10.1002/food.19900340715

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✦ Synopsis

N-nitrosomorpholine biosynthesis and inhibition in mice treated with nitrate, morpholine and ascorbic acid, was studied by means of the mutagenic activity in urinesamples. The preincubation method was used and Salmo- nella ryphimurium TA 1535 was the test strain. The results suggest that N-nitrosomorpholine biosynthesis was carriedout when theanimalswerefedhighdosesofnitrate, howeverascorbicacid wasaninhibitor ofthis process.

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