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Mutagenicity of kaempferol in V79 cells: The role of cytochromes P450

โœ Scribed by I. Duarte Silva; A. Rodrigues; J. Gaspar; R. Mala; A. Laires; J. Rueff

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
626 KB
Volume
16
Category
Article
ISSN
0270-3211

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โœฆ Synopsis

The flavonol kaempferol is widely found in the diet and is directly mutagenic in some short-term tests, such as the induction of chromosomal aberrations in eukaryotic cells. The presence of exogenous metabolizing systems enhances its mutagenicity. We have evaluated the role of cytochromes P450 in the induction of chromosomal aberrations by kaempferol in V79 cells. The results obtained suggest that there is a timedependent biotransformation of kaempferol to quercetin, by cytochromes P4.50, as assessed by high pressure liquid chromatography. Quercetin seems to contribute to the mutagenicity of kaempferol in the presence of microsomal metabolizing systems. On the other hand, the direct induction of chromosomal aberrations by kaempferol does not seem to depend on the production of reactive oxygen species. o 1997 Wiiey-Liss, Inc.

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