Mutagenicity of cosmetic products containing Kathon® (Environ Mol Mutagen 28:127-132)

✍ Scribed by Thomas H. Connor

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 15 KB
• Volume: 29
• Category: Article
• ISSN: 0893-6692
• DOI: 10.1002/(sici)1098-2280(1997)29:3<330::aid-em14>3.0.co;2-f

✦ Synopsis

Since our publication of the article ''Mutagenicity of cos-cluded that Kathon in the drinking water of rats did not increase the incidence of tumors at these doses. metic products containing Kathon'' appeared in Environmental and Molecular Mutagenesis, we have obtained 3. The shampoo/conditioner reported on in Table VI contained 16.9 ppm active ingredients as determined by some new information relating to its potential carcinogenicity. The following information should be included:

Rohm and Haas Company and was in the range of the recommended concentration of 15 ppm active ingredients. Therefore, the high toxicity observed with this 1. We apparently miscalculated the dose of the active ingredients the mice received in the 30-month cancer product was either the result of another toxic component or a combination of components in this product bioassay. It should have been 500 mg/kg rather than the 5mg/kg as we reported.

and not an excess of Kathon as we had speculated. 2. A recent unpublished drinking water bioassay was carried out by the manufacturer (Rohm and Haas Company, 1994). The 24-month study included doses of 0, 0 (salt