Fetal cells are present in the circulation of pregnant women and can be isolated using density gradient centrifugation and magnetic cell sorting. In the present study, maternal cell preparations were depleted for CD45and CD14-positive cells and enriched for CD71-positive cells. The number of fetal n
Mutagenicity of cidial (phenthoate). I: Effect on maternal and fetal somatic cells
β Scribed by S.M. El Nahas; M.F. Abdel Samad; H.A. de Hondt
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 56 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0893-6692
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β¦ Synopsis
Cidial, an organophosphorous insecticide (also mosomal aberrations in both mothers and fetuses. known as phenthoate), was tested for its genotoxic It also significantly inhibited the rate of mitotic activeffect on both maternal and fetal cells. Cidial was ity of both maternal and fetal cells, with the inhibiadministered at three different dose levels (53.5, tory effect being more appreciable in fetal cells than 106.9, and 171 mg/kg) to pregnant mice on day in maternal cells. The data indicate that cidial, 16 of gestation. Maternal bone marrow and embry-which is widely used in rural areas, is hazardous onic liver cells were examined for chromosomal ab-to both mothers and their transplacentally exposed errations and cellular proliferation. Cidial was babies.
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