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Mutagenicity of 4,4′-MethyIenedianiline Derivatives in the Salmonella histidine reversion assay

✍ Scribed by T. K. Rao; G. F. Dorsey; B. E. Allen; J. L. Epler

Book ID: 104733335
Publisher: Springer-Verlag
Year: 1982
Tongue: English
Weight: 346 KB
Volume: 49
Category: Article
ISSN: 0340-5761
DOI: 10.1007/bf00347866

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✦ Synopsis

4,4'-Methylenedianiline and its derivatives were assayed for mutagenicity in the Salmonella/microsomal mutagenicity assay developed by Ames. A specificity to revert strain TA98 suggests a mechanism of frameshift mutagenesis. Liver microsomal preparations (S-9) from rats induced with phenobarbital were most effective for metabolic activation. Alkyl substitution of 4,4'-methylenedianiline did not alter its mutagenic activity; however, substitution of both positions ortho to the amino group eliminated mutagenic activity. Substitution with alkoxy-carbonyl groups eliminated mutagenic activity, whereas halogen substitution (chlorine, fluorine) enhanced the mutagenic activity. The results presented here show the use of structure-activity studies as predictive tools for the assessment of genotoxic properties of industrial chemicals.

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