The chlorinated drinking water mutagen 3-chloro-4-methyl-5-hydroxy-2(5H)-furanone (MCF) occurs at concentrations similar to or greater than that of the related furanone 3-chloro-4-(dichloromethyl)-5hydroxy-2(5H)-furanone (MX). MCF and MX differ structurally only by replacement of a 3-methyl in MCF w
✦ LIBER ✦
Mutagenicity in vitro of 3,4-dichloro-5-hydroxy-2(5H)-furanone (mucochloric acid), a chlorine disinfection by-product in drinking water
✍ Scribed by Kristian Jansson; Juha M. T. Hyttinen; Minna Niittykoski; Jorma Mäki-Paakkanen
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 308 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0893-6692
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The frequency of point mutations in p53 (exons 4 -7) and in Ki-ras, Ha-ras, and N-ras (exons 1 and 2) and the expression of p53 protein were evaluated in the liver tumors of Wistar rats of a 104week carcinogenicity study on 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), a chlorine disinf