𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Mutagenicity evaluation of tetrahydro-amino acridine by the Salmonella/microsome mutagenicity ames test

✍ Scribed by Steven E. Townsend; Dr. Suren N. Sehgal

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
173 KB
Volume
14
Category
Article
ISSN
0272-4391

No coin nor oath required. For personal study only.

✦ Synopsis

Townsend, S.E., and S.N. Sehgal: Mutagenicity evaluation of tetrahydro-amino acridine by the Salmonella/microsome mutagenicity Ames test. Drug Dev. Res. 14:91-94, 1988. 1,2,3,4-tetrahydr0-5-amino acridine (THA), a cholinesterase inhibitor currently under investigation for use in the treatment of senile dementia, exhibited mutagenic activity with and without metabolic microsomal S-9 activation against tester strain TA97a in the Salmonella fyphimurium incorporation assay. The mutagenic response was concentration-dependent within the dose range of 500 to 2,500 Fg/plate.

📜 SIMILAR VOLUMES

Comparison of the Salmonella/microsome m
Comparison of the Salmonella/microsome microsuspension assay with the new microplate fluctuation protocol for testing the mutagenicity of environmental samples
✍ Gisela de Aragão Umbuzeiro; Célia Maria Rech; Simone Correia; Ana Marcela Bergam 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 106 KB 👁 1 views

## Abstract The objective of this study was to compare the responses of the Salmonella/microsome microsuspension assay with the new microplate fluctuation protocol (MPF) for the evaluation of the mutagenic activity of environmental samples. Organic extracts of total particulate atmospheric air samp

Further development of the β-lactamase M
Further development of the β-lactamase MutaGen assay and evaluation by comparison with Ames fluctuation tests and the umu test
✍ Georg Reifferscheid; Christian Arndt; Claudia Schmid 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 394 KB

## Abstract A rapid, high‐throughput bacterial mutagenicity test system has been developed (MutaGen test) that detects reversions of inactivating base‐pair substitutions and frameshifts in a TEM‐1 class A β‐lactamase (ampicillinase) gene. To quickly and sensitively detect mutagens, the system utili