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Mutagenicity and cytotoxicity of reactive oxygen and nitrogen species in the MN-11 murine tumor cell line

✍ Scribed by Jagdeep K Sandhu; H.Chaim Birnboim

Book ID
114071340
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
194 KB
Volume
379
Category
Article
ISSN
0027-5107

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## Abstract Manumycin‐A (Man‐A) is a farnesyltransferase inhibitor (FTI), which was originally identified as an effective tumoricide against several cancers, especially ones harboring constitutively active Ras. However, it is becoming apparent that Man‐A can stimulate tumor death independently of F