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Mutagenicity and cytotoxicity of 2-chlorobenzylidene malonitrile (CS) and metabolites in V79 Chinese hamster cells

✍ Scribed by Kyriakoula Ziegler-Skylakakis; Karl Heinz Summer; Ulrich Andrae


Book ID
104700564
Publisher
Springer-Verlag
Year
1989
Tongue
English
Weight
526 KB
Volume
63
Category
Article
ISSN
0340-5761

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The N-acetoxy and N-hydroxy derivatives of trans-4-acetylaminostilbene (AAS) were demonstrated to induce gene mutations at the hgprt locus and to be cytotoxic in V79 cells. These cells deacetylated AAS. Paraoxon inhibited the deacetylation of AAS by more than 99% and reduced the mutagenicity and cyt