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Mutagenic specificity of the base analog 6-N-hydroxylaminopurine in the LYS2 gene of yeast Saccharomyces cerevisiae

โœ Scribed by Vladimir V. Kulikov; Irina L. Derkatch; Vladimir N. Noskov; Olga V. Tarunina; Yury O. Chernoff; Igor B. Rogozin; Youri I. Pavlov


Book ID
114070302
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
128 KB
Volume
473
Category
Article
ISSN
0027-5107

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HAM1, the gene controlling 6-N-hydroxyla
โœ Noskov, V. N.; Staak, K.; Shcherbakova, P. V.; Kozmin, S. G.; Negishi, K.; Ono, ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 923 KB

The haml mutant of yeast Saccharomyces cerevisiae is sensitive to the mutagenic and lethal effects of the base analog, 6-N-hydroxylaminopurine (HAP). We have isolated a clone from a centromere-plasmid-based genomic library complementing HAP sensitivity of the haml strain. After subcloning, a 3.4 kb