✍ Scribed by K. Gasiorowski; K. Szyba; J. Urban; M. Cieslak-Golonka; S. M. Zakeeruddin; M. Grätzel; D. M. Fraser
No coin nor oath required. For personal study only.
Five novel tris-(4,4'-substituted-2,2'-bipyridine) complexes of the group VIII metals [Fe(ll), Ru(ll) and Os(ll)] (all having been previously examined electrochemically with respect to their ability to act as electron-transfer mediators for redox enzymes) were assayed in the Ames test to evaluate their mutagenic activity. For the bipyridine complexes, some complexes did exhibit mutagenic activity in the circumstances of this test, whereas others did not. this is comparable to the results known from the literature for ferrocene mediators. There was no specific correlation with the identities of the metal and ligand type; the possible explanations of the results are discussed in this paper. It seems probable that the penetration of the whole compound inside bacterial cells depends on the organic part of a complex, with only then the possible genotoxic activity of the complex being revealed. In view of our mutagenic test results, such complexes found to be mutagenic should not be taken into consideration as components of implanted glucose sensors in future in vivo experiments.
📜 SIMILAR VOLUMES