Mutagenic Activity of Acrolein in S. typhimurium and E. coli

✍ Scribed by Richard A. Parent; Halina E. Caravello; Richard H. C. San

• Book ID: 102659263
• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 546 KB
• Volume: 16
• Category: Article
• ISSN: 0260-437X
• DOI: 10.1002/(sici)1099-1263(199603)16:2<103::aid-jat318>3.0.co;2-q

✦ Synopsis

Acrolein was tested for mutagenic activity in seven strains of Salmonella typhimurium and one strain of Escherichia coli using a preincubation assay procedure. Cytotoxicity was evident at dosing levels above 33 and 67 p g acrolein per plate in the absence and presence of S-9 activation, respectively. Evidence of mutagenic activity was seen at non-toxic dosing levels in S. typhimurium strains TA98 and TAlOO and E. coli strain WP2 uvrA. Responses in TA98 and E. coli were marginal at best, but a firm positive mutagenic activity was noted in TAlOO at 20 pg per plate without S-9 activation and at 67 pg per plate with S-9 activation. The results of this study demonstrate the mutagenicity of acrolein under highly controlled conditions.