Mutagenic activity and identification of excreted platinum in human and rat urine and rat plasma after administration of cisplatin
β Scribed by Safirstein, R.; Daye, M.; Guttenplan, Joseph B.
- Book ID
- 121965520
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- English
- Weight
- 741 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0304-3835
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Numerous n-heptane metabolites have been identified and quantified by gas chromatography and mass spectrometry in some tissues and in the urine of Sprague Dawley rats exposed for 6 h to 1800 ppm n-heptane. 2-Heptanol and 3-heptanol were the main biotransformation products of the solvent. 2-Heptanone
3-hydroxy-benzo(a)pyrene (3-OH-B(a)P) and mutagenic activity in rat urine were determined after the oral administration of benzo(a)pyrene given in three repeated doses of 10, 20 and 50 pmol kg-'. The procedure for the determination of 3-OH-B(a)P consisted of enzymic hydrolysis, separation and HPLC-a