Mutagenesis of yeast MW104-1B strain has identified the uncharacterized PMS6 DNA mismatch repair gene locus and additional alleles of existing PMS1, PMS2 and MSH2 genes

Promoter methylation and expression of M

Promoter methylation and expression of MGMT and the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2 in paired primary and recurrent glioblastomas

✍ Jörg Felsberg; Niklas Thon; Sabina Eigenbrod; Bettina Hentschel; Michael C. Sabe 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 French ⚖ 534 KB

## Abstract Epigenetic silencing of the O^6^‐methylguanine‐DNA methyltransferase (__MGMT__) gene promoter is associated with prolonged survival in glioblastoma patients treated with temozolomide (TMZ). We investigated whether glioblastoma recurrence is associated with changes in the promoter methyl