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Mutagenesis of L5178Y/TK+ / − −3.7.2C mouse lymphoma cells by the clastogen ellipticine

✍ Scribed by Moore, Martha M. ;Brock, Karen H. ;Doerr, Carolyn L. ;Demarini, David M.


Publisher
Wiley (John Wiley & Sons)
Year
1987
Weight
647 KB
Volume
9
Category
Article
ISSN
0192-2521

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✍ Moore, Martha M. ;Brock, Karen H. 📂 Article 📅 1988 🏛 Wiley (John Wiley & Sons) ⚖ 187 KB

One of the mammalian cell gene-mutation assays that has been used extensively for mutagenicity studies is the L5178Y/TK+'--3.7.2C mouse lymphoma assay Oberly et al., 19841. This assay measures forward mutation at the functionally heterozygous thymidine kinase (rk) locus based on resistance to trifl