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Mutagenesis by N-nitroso compounds: relationships to DNA adducts, DNA repair, and mutational efficiencies

✍ Scribed by J.B. Guttenplan

Book ID
113193873
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
938 KB
Volume
233
Category
Article
ISSN
0027-5107

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## Abstract O^6^‐methylguanine‐DNA methyltransferase (MGMT) is a repair protein that specifically removes promutagenic alkyl groups from the O^6^ position of guanine in DNA. __MGMT__ is transcriptionally silenced by promoter hypermethylation in several human cancers. Methylation‐specific PCR (MSP)