Mutagenesis and human genetic disease: An introduction
β Scribed by Vicki L. Dellarco; Robert P. Erickson; Susan E. Lewis; Michael D. Shelby
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 576 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0893-6692
No coin nor oath required. For personal study only.
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In the Human Gene Mutation Database (www.hgmd.org), microdeletions and microinsertions causing inherited disease (both defined as involving < or = 20 bp of DNA) account for 8,399 (17%) and 3,345 (7%) logged mutations, in 940 and 668 genes, respectively. A positive correlation was noted between the m
## Abstract Repetitive DNA motifs may fold into nonβB DNA structures, including cruciforms/hairpins, triplexes, slipped conformations, quadruplexes, and leftβhanded ZβDNA, thereby representing chromosomal targets for DNA repair, recombination, and aberrant DNA synthesis leading to repeat expansion