Muscular dystrophy associated with extra-abdominal desmoid tumor showing aberrant chromosome 1 [46,XX,add(1)(p36)]
✍ Scribed by Katsuura, Michihiko; Kato, Mitsuhiro; Sendo, Dai; Akiba, Kaori; Honma, Akira; Takahashi, Yumiko; Numakura, Chikahiko; Yokoyama, Shinkichi; Nonaka, Ikuya; Shibata, Takanori; Hayasaka, Kiyoshi
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 7 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0148-7299
No coin nor oath required. For personal study only.
✦ Synopsis
We report on a 2-year-old girl with probable limb-girdle muscular dystrophy associated with an extra-abdominal desmoid tumor of the right mandible. This association is previously undescribed. The tumor was totally removed. Cytogenetic analysis of the tumor showed a clonal karyotypic abnormality: 46,XX,add(1)(p36) in 3 of 20 cells analyzed. Since an association of a neoplasm with limb-girdle muscular dystrophy has previously been reported in 3 cases, the two abnormalities are likely related causally. The chromosome abnormality in our patient may play a role in the occurrence of her desmoid tumor. Am.