Muscle stiffness and electrical activity in paramyotonia congenita
✍ Scribed by Dr. Kenneth Ricker; Dr. Reinhardt Rüdel; Frank Lehmann-Horn; Gerald Küther
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 660 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0148-639X
No coin nor oath required. For personal study only.
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Twitch force and Na' currents were investigated in a muscle biopsy specimen from a patient with paramyotonia congenita carrying the dominant Arg-1448-Pro mutation in the skeletal muscle sodium channel. Cooling of the muscle fibers caused sustained membrane depolarization that resulted in reduced twi
A 47-year-old female with paramyotonia congenita was studied with electromyography and showed minimal myotonic discharges but prominent repetitive discharges in hand muscles at room temperature. With cooling the hand, the repetitive discharges ceased as the myotonic potentials became prominent. With