Muscle phosphorus magnetic resonance spectroscopy oxidative indices correlate with physical activity

✍ Scribed by M. Carmela Tartaglia; Jacqueline T. Chen; Zografos Caramanos; Tanja Taivassalo; Douglas L. Arnold; Zohar Argov

• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 184 KB
• Volume: 23
• Category: Article
• ISSN: 0148-639X
• DOI: 10.1002/(sici)1097-4598(200002)23:2<175::aid-mus5>3.0.co;2-r

✦ Synopsis

The purpose of this study was to assess the effect of physical deconditioning on skeletal muscle's oxidative metabolism as evaluated by phosphorus-31 magnetic resonance spectroscopy ( 31 P MRS). Twentyseven subjects without muscle disease, representing a wide range of fitness levels, were evaluated with 31 P MRS. Spectra were obtained at rest and during recovery from in-magnet exercise. The data show a significant correlation between maximum resting metabolic equivalent (MET) score and the following 31 P MRS recovery indices: adenosine diphosphate and phosphocreatine recovery half-time; initial phosphocreatine resynthesis rate; calculated estimation of mitochondrial capacity; pH at end of exercise; and phosphocreatine depletion. In addition, significant differences between the deconditioned and conditioned group were found for all of the aforementioned recovery indices. At rest, only the inorganic phosphate concentration was significantly different between the two groups. These data indicate that physical activity level should be taken into account when assessing patients' oxidative metabolism with 31 P MRS.