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Muscle histopathology in myotonic dystrophy in relation to age and muscular weakness

โœ Scribed by Hideo Tohgi; Atsushi Kawamorita; Kimiaki Utsugisawa; Munehisa Yamagata; Mitsuhiko Sano

Book ID
102956490
Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
699 KB
Volume
17
Category
Article
ISSN
0148-639X

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## Abstract Myotonic muscular dystrophy (DM) is characterized by abnormal skeletal muscle Na channel gating and reduced levels of myotonic dystrophy protein kinase (DMPK). Electrophysiological measurements show that mice deficient in __Dmpk__ have reduced Na currents in muscle. We now find that the