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Muscle energy metabolism in female DMD/BMD carriers: A 31P-MR spectroscopy study

✍ Scribed by Prof. Dr. Bruno Barbiroli; Dr. Rosanna Funicello; Dr. Alessandra Ferlini; Dr. Pasquale Montagna; Dr. Paolo Zaniol

Book ID
102537353
Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
443 KB
Volume
15
Category
Article
ISSN
0148-639X

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✦ Synopsis

Abstract

^31^P nuclear magnetic resonance spectroscopy (^31^P‐MRS) was used to investigate the energy metabolism of the gastrocnemius muscle in 16 DMD/BMD female carriers. No significant difference was found with the controls in the resting muscle, while all carriers showed a decreased ability to perform work, and a higher Pi/PCr ratio for comparable relative levels of steady‐state work. The rate of postexercise recovery of PCr/Pi ratio was lower in all carriers. The decreased rate of PCr/Pi recovery appears to be mainly due to a decreased rate of Pi recovery. Our findings show abnormal muscle energy metabolism in DMD/BMD female carriers.

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