Muscle degeneration following remote nerve injury

✍ Scribed by Personius, K. E. ;Arbas, E. A.

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 281 KB
• Volume: 36
• Category: Article
• ISSN: 0022-3034
• DOI: 10.1002/(sici)1097-4695(19980915)36:4<497::aid-neu4>3.0.co;2-r

✦ Synopsis

Muscle depends upon innervation evident and electrophysiological changes were found and contraction to maintain a differentiated state. Dein all animals tested. Muscle anatomical degeneration nervation can therefore induce muscle atrophy. In grasshoppers, muscle degeneration can also be trigwas not induced by synaptic transmission failure, begered by the severing of a leg during autotomy. In cause neuromuscular transmission was maintained in this case, the muscles that degenerate are neither dammost fibers. The rate of muscle degeneration was not aged nor denervated. This phenomenon suggests the constant. Between 1 and 10 days, mean fiber crossexistence of transneuronal mechanisms that influence sectional area did not change on the autotomized side, muscle survival. To characterize this autotomy-inalthough this is normally a time of muscle growth. duced process, we studied the degeneration of a tho-However after 10 days, cross-sectional area became racic tergotrochanteral depressor muscle (M#133b,c) drastically reduced and the number of muscle fibers subsequent to the shedding of a hindlimb in the grasswithin M#133b,c was decreased. The variability in hoppers Barytettix psolus and Barytettix humphreysii. rate of fiber degeneration was not dependent upon Both histochemical and electrophysiological methods fiber type, since M#133b,c only contains fast-type were used to follow muscle degeneration 1, 3, 5, 10, fibers.