Muscarinic receptor pathways in nonfailing and failing human heart
β Scribed by Ray E. Hershberger; Jordon A. Kimball; Wayne Minobe; Randy Rasmussen; Michael R. Bristow
- Book ID
- 118414686
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 348 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1558-3597
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π SIMILAR VOLUMES
Disturbances in the cAMP production during beta-adrenergic stimulation and alterations of Ca2+ transport controlling proteins and their regulation in the sarcoplasmic reticulum might be involved in the pathogenesis of the failing human heart. Thus, we investigated the cAMP-mediated phosphorylation o
Total beta-adrenoceptor density and beta 1- and beta 2-subtype distribution in right and left atria and in different ventricular regions from 14 failing and seven nonfailing human hearts have been compared. End-stage heart failure was due to idiopathic dilated cardiomyopathy (n = 8) or ischaemic car
To identify possible alterations of the L-type calcium currents (I(Ca),L) in cardiomyopathy, I(Ca),L were recorded in atrial myocytes dissociated from the nonfailing heart (NF) of patients undergoing corrective open-heart surgery and explanted failing heart (FH) of patients with dilated cardiomyopat