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Muscarinic receptor-linked elevation of cAMP in SH-SY5Y neuroblastoma cells is mediated by Ca2+ and protein kinase C

✍ Scribed by Christian C. Jansson; Jyrki Kukkonen; Karl E.O. Åkerman


Book ID
119121340
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
285 KB
Volume
1095
Category
Article
ISSN
0167-4889

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The effects of phorbol esters on Ca 2 + channel currents in human neuroblastoma SH-SY5Y cells were studied using whole-cell patch-clamp recordings. Bath application of 12-O-tetradecanoylphorbol-13-acetate (TPA) or phorbol 12, 13-dibutyrate (PDBu; 100 nM to 1 #M), known activators of protein kinase C