β Scribed by Dick, Michael R.; Dripps, James E.; Orr, Nailah
No coin nor oath required. For personal study only.
A series of known agonists of the mammalian muscarinic receptor were prepared and evaluated for their insecticidal potential. It was discovered that pests such as Nilaparvata lugens (brown planthopper), Nephotettix cincticeps (green leafhopper), T etranychus urticae (two-spotted spider mite) and Aphis gossypii (cotton aphid) were particularly sensitive to most of these compounds. Several analogs proved to be extremely active, surpassing commercial standards in some of the laboratory bioassays. These compounds exhibited a range of potencies for the insect (Musca) muscarinic receptor. Addition of GTP signiΓcantly reduced the affinity of the most potent analog for the Musca mAChR, indicating the compound functions as an agonist in insect tissue. Regression analysis indicated that signiΓcant relationships exist between displacement of [3H]QNB at the Musca muscarinic receptor and whole organism toxicity to three insect and one mite species. The results suggested that the insect muscarinic receptor represents a viable target site for insecticidal action.
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## Abstract The binding of one irreversible and two reversible radioactive antagonists to muscarinic receptors in synaptosome preparations of rat cerebral cortex has been studied. The ligands all bind to the same receptor pool and directly and competitively yield selfβconsistent binding constants c
The present study reports on the insecticidal and acaricidal potentials of dibenzyltrisulΓde (DBTS) isolated from the roots of Petiveria alliacea L. using thin layer and high performance liquid chromatography. The 96-h value (kg per tick) obtained for adult Boophilus microplus LD 50 (Canestrini) to
The object of this review paper is to provide a guide to agrochemical research involving organotin compounds which has been performed since 1980. The information is presented in a tabular form and is divided into four main sections as indicated by the title. Each section is then subdivided to cover