✦ LIBER ✦

MUSCARINIC ACETYLCHOLINE RECEPTOR SUBTYPE mRNAs IN THE HUMAN AND RAT VESTIBULAR PERIPHERY

✍ Scribed by PHILLIP A. WACKYM; CAROLINE T. CHEN; AKIRA ISHIYAMA; ROBERT M. PETTIS; IVÁN A. LÓPEZ; LARRY HOFFMAN

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 493 KB
Volume: 20
Category: Article
ISSN: 1065-6995
DOI: 10.1006/cbir.1996.0023

No coin nor oath required. For personal study only.

✦ Synopsis

The expression of the five muscarinic acetylcholine receptor (mAChR) subtypes (m1-m5) in the vestibular end-organs and in the primary afferent vestibular ganglia of the human and rat was studied using RT-PCR from the two tissue populations from both species. In the human, although all five mAChR subtypes were expressed in brain, only the m1, m2, and m5 mAChR subtypes were amplified from both the vestibular ganglia and the vestibular end-organs, while in the rat, all five mAChR subtypes were expressed. These data suggest that the efferent cholinergic axo-dendritic and axo-somatic synapses have a muscarinic component and that there are pharmacologic implications for patients with vestibular dysfunction.

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