MURINE LYMPHOCYTE ALLOANTIGENS: THE Ly-4 LOCUS
β Scribed by McKenzie, T. A. Potter, I. F. C. ;Cherry, M. C.
- Book ID
- 114830571
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- English
- Weight
- 594 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0960-7420
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Monoclonal antibodies to routine lymphocyte cell membrane alloantigenic determinants (CMAD) have proven valuable as tools for serological, genetic, and functional studies. An expansion of the library of murine CMAD would be facilitated by an increase in the repertoire of antibodies. We report here a
Using a monoclonal antibody raised by fusing spleen cells from A/J mice, immunized with B10.A splenocytes and lymph-node cells, with a BALB/c myeloma, we have described a new surface alloantigen, Ly-21.2. Ly-21.2 is present in varying amounts in all lymphoid tissues, is not detectable in the brain,