𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Murine genotype influences the in vitro production of γ (immune) interferon

✍ Scribed by Jean-Louis Virelizier

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
306 KB
Volume
12
Category
Article
ISSN
0014-2980

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Spleen cells from mice of 6 different strains were stimulated with pokeweed mitogen and the amount of γ interferon in the supernatants was measured. Three strains (BALB/c, A/J and C3H/He) were found to be low producers (less than 50 units) whereas three other strains (C57BL6, CBA and AKR) were high producers (50 to 500 units). F~1~ hybrids between a low producer strain (A/J) and a high producer strain (C57BL6) were found to produce low amounts of interferon. Nude mice did not produce detectable amounts of pokeweed mitogen‐induced γ interferon. The level of production of this T cell lymphokine is thus under genetic control.

📜 SIMILAR VOLUMES

Different amplifying mechanisms of inter
Different amplifying mechanisms of interleukin-17 and interferon-γ in Fcγ receptor–mediated cartilage destruction in murine immune complex–mediated arthritis
✍ Lilyanne C. Grevers; Peter L. E. M. van Lent; Marije I. Koenders; Birgitte Walgr 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 341 KB 👁 1 views

## Abstract ## Objective Previously, we reported that interferon‐γ (IFNγ) aggravates cartilage destruction in immune complex (IC)–mediated arthritis via up‐regulation of activating Fcγ receptors (FcγR). Recently, we found that interleukin‐17 (IL‐17) also aggravates cartilage destruction in arthrit

T cell response in murine Leishmanial me
T cell response in murine Leishmanial mexicana amazonensis infection: production of interferon-γby CD8+ cells
✍ Marion Man-Ying Chan 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 456 KB

## T cell response in murine Leishmania mexicana amazonensis infection: production of interferon-y by CDS+ cells* The immune response to Leishmania major has been the subject of many investigations. However, Leishmania includes many species with different clinical manifestations. In this report, w

Production of interferon in the murine m
Production of interferon in the murine mixed lymphocyte culture. II. Interferon production is a T cell-dependent function, independent of proliferation
✍ Holger Kirchner; Rainer Zawatzky; Helmut Engler; Volker Schirrmacher; Hans Becke 📂 Article 📅 1979 🏛 John Wiley and Sons 🌐 English ⚖ 337 KB

## Abstract Interferon production occurs after two days of culture in murine mixed lymphocyte cultures (MLC). This was demonstrated in various combinations of mouse spleen cells differing at the major histocompatibility (H‐2) locus. Interferon production could be demonstrated in one‐way MLC when F~