Murine epidermal γ/δ T cells express Fcγ receptor II encoded by the FcγRα α gene
✍ Scribed by William A. Kuziel; Julia Lewis; Jackie Nixon-Fulton; Robert E. Tigelaar; Philip W. Tucker
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 433 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0014-2980
No coin nor oath required. For personal study only.
✦ Synopsis
Short-term bulk cultures and some long-term clones and lines of murine T cell receptor (TcR) y/a-bearing epidermal Tcells (dEC) were found to express an Fcy receptor I1 (FcyRII), as revealed by reactivity with the monoclonal antibody 2.462. Northern blot analysis showed that the FcyRII expressed on dEC is encoded solely by the FcyRa gene. While all the various cultured dEC cell populations analyzed exhibit lectin-dependent cellular cytotoxicity, only those which expressed FcyR a were also capable of mediating antibody-dependent cellular cytotoxicity (ADCC). These results in combination with the previous demonstration of FcyR a on mouse natural killer cells support an essential role for FcyR a in ADCC and extend an analogy with surface CD16 (FcyRIII) expression and ADCC in human natural killer cells and peripheral TcRy/6 Tcells.